Travel vaccination

Cholera Vaccination (Dukoral)

Dukoral is an oral vaccine that helps protect against cholera and may offer some protection against certain causes of travellers' diarrhoea. It is taken as a drink before travel to higher-risk areas.

£35 per dose

£35 per dose — 2 dose course

Who it is for

Adults and children aged 2 years and over who are at higher risk, such as aid and relief workers, volunteers and travellers to outbreak areas with limited access to safe water and medical care

Number of doses

Two doses for adults and children aged 6 years and over; three doses for children aged 2 to 5 years

When to have it

Complete the course at least one week before you are at risk of exposure

How long protection lasts

Around two years in adults, after which a booster may be advised for those at continued risk

How it is given

Taken by mouth as a drink mixed with water and a buffer solution, not as an injection

Price

£35 per dose

Quick answer

Dukoral is an oral cholera vaccine taken as a drink, given as two doses before travel, and may offer some protection against certain causes of travellers' diarrhoea. It is mainly recommended for aid workers and travellers to outbreak areas rather than routine tourists. The Dukoral cholera vaccine is available at Crewe Travel Clinic in Crewe, Cheshire.

About Cholera Vaccination (Dukoral)

Cholera is a bacterial infection spread through food and water contaminated with the bacterium Vibrio cholerae. It can cause severe, watery diarrhoea and rapid dehydration, and tends to occur in areas with poor sanitation, particularly during outbreaks, natural disasters or in refugee settings.

Dukoral is an oral, inactivated vaccine taken as a drink mixed with water. For most adults it is given as two doses, spaced at least one week (and no more than six weeks) apart, with the course completed before travel. It is generally reserved for travellers at higher risk rather than routine tourists.

Dukoral may also provide some short-term protection against travellers' diarrhoea caused by certain strains of E. coli. At Crewe Travel Clinic we can assess your itinerary and advise whether Dukoral is appropriate, alongside essential food and water precautions.

Timing

Complete the course at least 1 week before travel

The two doses are taken at least one week apart, and the final dose should be completed at least one week before you are at risk of exposure.

Effectiveness

Good short-term protection

Dukoral provides good protection against cholera in the months following the course, with protection gradually declining over time.

Duration

Around 2 years

Protection against cholera lasts around two years in adults, after which a booster dose may be advised for those at continued risk.

Signs & symptoms

  • Profuse, watery diarrhoea, often described as resembling rice water
  • Vomiting and nausea
  • Rapid and potentially severe dehydration
  • Intense thirst and a dry mouth
  • Leg cramps and muscle cramps
  • Reduced urine output, tiredness and, if untreated, shock

Who should consider this vaccine?

Dukoral is recommended for humanitarian aid workers; travellers going to areas with current cholera outbreaks who have limited access to safe water and medical care; and other travellers to cholera risk areas for whom vaccination is considered potentially beneficial because of their occupation, activities or underlying health. It is not needed for most standard tourist trips. Dukoral is not recommended for the prevention of travellers' diarrhoea, and good food and water hygiene remains essential.

High Risk Areas

Cholera risk is highest in parts of sub-Saharan Africa, South and South East Asia, and areas affected by conflict, flooding or natural disasters where sanitation and clean water are limited.

Traveller Risk Factors

Those most likely to benefit include aid, relief and healthcare workers, volunteers, people travelling to active outbreak areas or refugee settings, and travellers with limited access to safe water and medical care.

Who should have this vaccine

Cholera vaccination with Dukoral is not needed for most standard tourist trips. It is generally reserved for people whose work, activities or circumstances place them at higher risk of exposure to contaminated food and water. At Crewe Travel Clinic we review your destination, itinerary and health before advising whether the vaccine is appropriate for you.

  • Aid, relief and disaster-response workers travelling to affected areas
  • Healthcare workers and volunteers in regions with active cholera outbreaks
  • Travellers going to areas with current outbreaks who have limited access to safe water and medical care
  • People living or working in refugee settings or following natural disasters or flooding
  • Not recommended for the routine prevention of travellers' diarrhoea

The vaccination course

Dukoral is an oral, inactivated vaccine taken as a drink. The vaccine is mixed with a buffer solution and water and swallowed; food and drink should be avoided for one hour before and after each dose. The number of doses depends on age, and the course should be completed before you are likely to be exposed.

  • Adults and children aged 6 years and over: two doses given at least one week apart
  • Children aged 2 to 5 years: three doses, each at least one week apart
  • Each dose should be taken no more than six weeks apart; if longer, the course may need to be restarted
  • Complete the full course at least one week before potential exposure

How long does protection last

Protection develops after the course is completed and is best in the months that follow, gradually declining over time. The need for a booster depends on whether you remain at risk and how long since your last dose.

  • Protection against cholera lasts around two years in adults
  • In children aged 2 to 5 years, a booster may be advised after about six months of continued risk
  • A booster dose may be considered for those with ongoing exposure
  • Good food and water hygiene remains essential at all times

Possible side effects

Dukoral is generally well tolerated. Because it is taken by mouth, most reported effects relate to the digestive system and are usually mild and short-lived. Serious reactions are uncommon. If you feel unwell after a dose or have any concerns, you can contact our team for advice.

  • Mild tummy discomfort, bloating or abdominal pain
  • Diarrhoea or loose stools
  • Nausea and, less commonly, vomiting
  • Headache or a general feeling of being unwell
  • Seek prompt medical advice if you have signs of a severe allergic reaction, which is rare

Frequently asked questions

Medically reviewed by Crewe Travel Clinic clinical team · Last reviewed 13 June 2026

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