Travel vaccination

Japanese Encephalitis Vaccination (Ixiaro)

Ixiaro protects against Japanese encephalitis, a mosquito-borne viral infection that can cause serious inflammation of the brain. It is recommended for travellers spending time in rural and agricultural areas of Asia and parts of the Pacific.

£95 per dose

£95 per dose — 2 dose course

Who it is for

Travellers spending longer periods in rural or agricultural areas of Asia and the western Pacific, particularly during the rainy season, and adults and children aged 2 months and over at risk.

Number of doses

Two doses to complete the primary course.

When to have it

The course should ideally be completed at least one week before travel, so starting in good time is advised.

How long protection lasts

Several years after the full primary course; a booster may be advised for those at continued risk.

How it is given

By injection into the upper arm, with the two doses normally 28 days apart.

Price

£95 per dose

Quick answer

Ixiaro is a two-dose vaccine that protects against Japanese encephalitis, a mosquito-borne brain infection found in rural parts of Asia and the western Pacific. It is recommended for travellers staying in affected rural areas, especially during the rainy season. The Ixiaro Japanese encephalitis vaccine is available at Crewe Travel Clinic in Crewe, Cheshire.

About Japanese Encephalitis Vaccination (Ixiaro)

Japanese encephalitis is a viral infection spread by mosquitoes that bite mainly during the evening and night, particularly in rural farming areas where rice fields and pig rearing are common. Most infections cause no symptoms, but a small number can lead to severe inflammation of the brain, which may be life-threatening or cause long-term disability.

The virus is found across much of Asia and parts of the western Pacific, with transmission often peaking during the rainy season. There is no specific treatment, so prevention through mosquito-bite avoidance and vaccination is essential for those at risk.

Ixiaro is given as a two-dose course and is suitable for adults and children. Your travel health nurse will assess your destination, length of stay, season of travel and planned activities to advise whether the vaccine is suitable for you.

Timing

Course completed at least 1 week before travel

The two doses are given 28 days apart, with the course ideally completed at least one week before travel; an accelerated schedule may be possible for adults.

Effectiveness

High level of protection

Completing the full two-dose course produces protective antibodies in the large majority of people who receive it.

Duration

Several years

Protection lasts for several years after the primary course, and a booster may be advised for those who remain at ongoing risk.

Signs & symptoms

  • High fever
  • Severe headache
  • Stiff neck
  • Confusion or disorientation
  • Seizures (more common in children)
  • Muscle weakness or paralysis

Who should consider this vaccine?

Vaccination may be advised for travellers spending longer periods in rural or agricultural parts of Asia, especially during the transmission season, or for those making repeated trips to affected areas. It is particularly worth considering for travellers staying near rice paddies, marshland or pig farming. Your travel health nurse will assess your itinerary and risk before recommending it.

High Risk Areas

Japanese encephalitis occurs across South and Southeast Asia, the Indian subcontinent, China, the Far East and parts of the western Pacific, with risk highest in rural and agricultural areas during the rainy season.

Traveller Risk Factors

Those most at risk include travellers spending a month or more in affected rural areas, those visiting during or just after the rainy season, expatriates and long-stay visitors, and people undertaking outdoor or agricultural activities. Even shorter trips may carry risk where extensive outdoor exposure is planned.

Who should have this vaccine

Japanese encephalitis vaccination may be advised for travellers whose itinerary places them at higher risk of mosquito bites in affected rural and agricultural regions. Risk is greatest during and shortly after the rainy season and in areas where rice cultivation and pig rearing are common. Your travel health nurse will weigh up your destination, length of stay, season of travel and planned activities before recommending the vaccine.

  • Travellers spending a month or more in rural or agricultural areas of affected countries
  • Those visiting during or just after the rainy season when transmission peaks
  • Expatriates, long-stay visitors and people making repeated trips to affected regions
  • Travellers undertaking extensive outdoor or agricultural activities, including near rice paddies or marshland
  • Suitable for adults and children from 2 months of age

The vaccination course

Ixiaro is given as a two-dose course, with the doses normally separated by 28 days. The course should ideally be finished at least one week before travel so that protection has time to develop. For adults who are short of time, an accelerated schedule with a shorter interval between doses may be possible. Booking early helps ensure the full course can be completed before departure.

  • Two doses given by injection into the upper arm
  • Standard interval of 28 days between the first and second dose
  • An accelerated schedule may be possible for adults aged 18 to 65
  • Aim to complete the course at least one week before travel

How long does protection last

Completing the full two-dose course produces protective antibodies in the large majority of people who receive it, giving protection that lasts for several years. A booster dose may be advised for those who continue to travel to or live in affected areas after the primary protection begins to wane. Vaccination should always be combined with careful mosquito-bite avoidance, as no vaccine offers complete protection.

  • Protection lasts for several years after the primary course
  • A booster may be advised for ongoing or repeated exposure
  • Mosquito-bite avoidance remains essential alongside vaccination

Possible side effects

Most side effects from Ixiaro are mild and short-lived, settling within a few days. Serious reactions are uncommon. Your travel health nurse will discuss any individual considerations, such as pregnancy, allergies or a weakened immune system, before the vaccine is given and will advise you on what to expect afterwards.

  • Soreness, redness or swelling at the injection site
  • Headache and muscle aches
  • Tiredness and a generally unwell feeling
  • Mild fever, more often in younger children
  • Serious allergic reactions are rare

Frequently asked questions

Medically reviewed by Crewe Travel Clinic clinical team · Last reviewed 13 June 2026

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